To achieve the overall scientific goal of our O’Brien Center, we propose 3 research projects to characterize molecular and cellular alterations associated with BPH pathogenesis using cultured cells, animal models, and/or human BPH specimens:
Project 1
Afferent and urothelial plasticity underlying bladder sensitization in prostatic inflammation
Project Leader: Naoki Yoshimura, M.D., Ph.D.
Personnel:
Naoki Yoshimura »
Suzuki Takahisa
Pradeep Tyagi »
Vickie L. Erickson
Lori Ann Birder »
Florenta Aura Kullmann »
Amanda Sue Wolf-Johnston
Project 2
Luminal epithelial junctions, polarity, and permeability in BPH pathogenesis
Project leader: Zhou Wang, Ph.D.
Personnel:
Zhou Wang »
Donna B. Stolz »
Aiyuan Zhang
Jianhua Zhou
Ke Wang
Wei Chen
Project 3
Impact of Cox-2 on protective effects of estrogen receptor beta (ERb) in prostate epithelial cell
Project leader: Donald Defranco, Ph.D.
Personnel:
Donald B. Defranco »
Kai He
Liping Wang
Stacy Lynn Wendell »
Uma R. Chandran »